Nervous system side effects may include seizures if the recommended dose of Ultram (tramadol) is exceeded. The risk of seizures or convulsions increases with the enlargement of the dose. Seizures have been reported in more than 200 cases.
Nervous system adverse reactions happen rather often. Dizziness, headaches, and somnolence are frequently met (in about 25%) of patients treated with tramadol in the first three months of therapy. Central nervous system activities such as nervousness, anxiety, tremor, agitation, euphoria and hallucinations can also occur. Confusion, insomnia, and difficulties with coordination have been reported in less than 5% of the patients involved in the studies. Other side effects of the nervous system are insignificant.
Gastrointestinal side effects are also very common. Vomiting, diarrhea, dyspepsia, anorexia, flatulence, abdominal pain, and stomach upset have been reported by many patients taking tramadol. Patients experience nausea and constipation during the first 3 months of therapy. These side effects occur in 40% and 46% of treated patients, correspondingly.
Urinary retention is a side effect from the genitourinary system. The other rare side effect is frequent urination which has been reported in less than 5% of patients.
Cardiovascular adverse reactions such as tachycardia, abnormal heart beat and orthostatic hypotension have been reported rarely.
Dermatologic side effects include pruritus (in 11% of patients), rarely – rash, and urticaria have been reported.
Metabolic side effect reported during studies was hyponatremia.